Job Description

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Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

• As a Senior Computational Chemistry Leader, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Data Scientist, Structural Biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects.
• This role supports small molecule research initiatives across Takeda research sites, leading computational chemistry efforts to drive project progression at both locations.
• Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts.

Accountabilities:

• Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
• Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
• Provide crucial technical knowledge and input to project teams to drive decisionmaking in drug discovery projects.
• Build and develop a strong team of Computational Chemists to high productivity levels.

Education & Competencies:

Technical/Functional (Line) Expertise

• Expertise in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modelling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity and diversity analysis.
• Significant industry experience contributing as a Computational Chemist on drug discovery projects.
• Strong impact in progressing discovery projects from hits to clinical leads.
• Extensive knowledge and experience in using a variety of tools for hit ID.
• Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/ selectivity and improve ADME/Tox endpoints.
• Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery.
• Proficiency with stateoftheart computational chemistry software.

Leadership

• Identifies, plans and executes novel scientific projects and leads platform initiatives.
• Experience in a supervisory role is strongly preferred.

EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:

• PhD degree in a scientific discipline with 7+ years of industry (pharma/biotech) drug discovery experience required.

ADDITIONAL INFORMATION

• The position will be based in Cambridge, MA. This position is currently classified as hybrid by Takedas Hybrid and Remote Work policy.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$153,600.00 - $241,340.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for shortterm and/ or longterm incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a401(k) plan and company match, shortterm and longterm disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and wellbeing benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

YesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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